In vitro transcription is a new technology that uses DNA templates to synthesize mRNA in vitro. Stemirna is one of the first companies in China to establish a full IVT mRNA platform. After continuous optimization of the platform, Stemirna is now able to synthesize mRNA of various lengths and functions, and has established a complete quality control system.
LPP (lipopolyplex) nano-delivery platform is a core-shell structure with polymer-mixed mRNA as the core and lipids as the shell. Compared with traditional LNP platforms, the core-shell structured LPP particle is better at protecting mRNA, and is able to release mRNA gradually as the polymers are degraded.
AI + Cloud Computing
Stemirna and Baidu have jointly developed the mRNA sequence optimized by LinearDesign to improve the stability and expression levels of the mRNA, empower the optimization of the mRNA sequence. The COVID-19 vaccine sequence designed by the algorithm is better than the consensus sequence designed by the traditional method. The collaboration will extend to circRNA and self-replicating mRNA.