| Registration Number | Clinical Center | Test Candidate | Indication | Objective of Study |
|---|---|---|---|---|
| ChiCTR1900023000 | Shanghai East Hospital of Tongji University | mRNA-based Personalized Cancer Vaccine | Advanced Malignant Solid Tumors | To explore the safety and efficacy of personalized cancer vaccine encoding neoantigen in the treatment of advanced malignant solid tumors. |
| NCT03468244 | Shanghai Changhai Hospital | mRNA-based Personalized Cancer Vaccine | Gastric Adenocarcinoma | To determine the safety, tolerability and cytokinetics and efficacy of the personalized mRNA tumor vaccine in patients with advanced esophageal squamous carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma and colorectal adenocarcinoma. |
| NCT03908671 | First Affiliated Hospital of Zhengzhou University | mRNA-based Personalized Cancer Vaccine | Esophageal Cancer, NSCLC | To assess the safety and tolerability and efficacy of mRNA personalized tumor vaccines encoding neoantigen for unresectable or metastatic advanced esophageal and non-small cell lung cancers with standard treatment failure or no standard treatment. |